5-Fluoroindole-2-carboxylic acid → 5-fluoro-2-{[4-(2-pyridinyl)-1-piperazinyl]carbonyl}-1H-indole

HRID 150517

Reaction equation

HRID 150517 reaction equation
[CH3:14][CH2:15][N:16]=[C:17]=[N:18][CH2:19][CH2:20][CH2:21][N:22]([CH3:23])[CH3:24].[Cl:37][CH2:38][Cl:39].[F:1][c:2]1[cH:3][c:4]2[cH:5][c:6]([C:11](=[O:12])[OH:13])[nH:7][c:8]2[cH:9][cH:10]1.[n:25]1[c:26]([N:31]2[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]2)[cH:27][cH:28][cH:29][cH:30]1>>[F:1][c:2]1[cH:3][c:4]2[cH:5][c:6]([C:11](=[O:13])[N:34]3[CH2:33][CH2:32][N:31]([c:26]4[n:25][cH:30][cH:29][cH:28][cH:27]4)[CH2:36][CH2:35]3)[nH:7][c:8]2[cH:9][cH:10]1

Participants

5

Reactant 4

HCID 18205-Fluoroindole-2-carboxylic acidHCID 6344DichloromethaneHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 944591-(2-Pyridyl)piperazine

Product 1

HCID 220659825-fluoro-2-{[4-(2-pyridinyl)-1-piperazinyl]carbonyl}-1H-indole

Sources & evidence

ORD record
ord-93bb2e7ed1f04168a32a7eccc403a5f0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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