Chlorosuccinimide → HCID 90280186, compound
Reaction equation
[CH:1](=[N:10][OH:11])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C1C(=O)N([Cl:19])C(=O)C1>CN(C=O)C>[OH:11][N:10]=[C:1]([Cl:19])/[CH:2]=[CH:3]\[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of cinnamaldoxime (10 g, 68 mmol) in DMF (100 mL) at room temperature was added solid NCS (9.08 g, 68 mmol). The suspension was stirred at room temperature overnight. The reaction mixture was poured into ice-water, extracted with a mixture of ethyl acetate and hexanes (7:3, 3×), dried with Na2SO4, concentrated and dried in vacuum to give the title compound.
Workup
- extractionextracted with a mixture of ethyl acetate and hexanes (7:3, 3×)
- dry with materialdried with Na2SO4
- concentrationconcentrated
- customdried in vacuum
Sources & evidence
- ORD record
- ord-9bcfa6fa51cd4bbab05c4af939d27f79
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09220710B2
Reaction notes
Loading…