4-Methylmorpholine → Methyl (5-chlorothiophene-2-carbonyl)alaninate

HRID 15097

Reaction equation

HRID 15097 reaction equation

C[C:2]1[CH:6]=[C:5]([Cl:7])[S:4][C:3]=1[C:8]([OH:10])=O.[NH2:11][CH:12]([CH3:16])[C:13]([O-:15])=[O:14].[CH3:17]N(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CN1CCOCC1>C1COCC1>[Cl:7][C:5]1[S:4][C:3]([C:8]([NH:11][CH:12]([CH3:16])[C:13]([O:15][CH3:17])=[O:14])=[O:10])=[CH:2][CH:6]=1

Participants

6

Reactant 4

HCID 79724-Methylmorpholine

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

HCID 5460975Alaninate

HCID 133762205-Chloro-3-methylthiophene-2-carboxylic acid

Product 1

HCID 60638172Methyl (5-chlorothiophene-2-carbonyl)alaninate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 1a from methyl 5-chloro-thiophene-2-carboxylic acid and 2-aminopropionate with TBTU and NMM in THF.

Sources & evidence

ORD record: ord-bb1475882c98444395d60f139ca030c2
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07732466B2

Linked notes

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