4-Methylmorpholine → Methyl (5-chlorothiophene-2-carbonyl)alaninate
Reaction equation
C[C:2]1[CH:6]=[C:5]([Cl:7])[S:4][C:3]=1[C:8]([OH:10])=O.[NH2:11][CH:12]([CH3:16])[C:13]([O-:15])=[O:14].[CH3:17]N(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CN1CCOCC1>C1COCC1>[Cl:7][C:5]1[S:4][C:3]([C:8]([NH:11][CH:12]([CH3:16])[C:13]([O:15][CH3:17])=[O:14])=[O:10])=[CH:2][CH:6]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared analogously to Example 1a from methyl 5-chloro-thiophene-2-carboxylic acid and 2-aminopropionate with TBTU and NMM in THF.
Sources & evidence
- ORD record
- ord-bb1475882c98444395d60f139ca030c2
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07732466B2
Reaction notes
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