4-Methylmorpholine → tert.-butyl(R)-2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionate
Reaction equation
C([C:5]1[CH:9]=[C:8]([Cl:10])[S:7][C:6]=1[C:11]([OH:13])=O)(C)(C)C.[NH2:14][C@H:15]([CH3:19])[C:16]([O-:18])=[O:17].CN(C(ON1N=NC2C=C[CH:33]=[CH:34][C:29]1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[CH3:42]N1CCOCC1>C1COCC1>[Cl:10][C:8]1[S:7][C:6]([C:11]([NH:14][C@H:15]([CH3:19])[C:16]([O:18][C:34]([CH3:33])([CH3:29])[CH3:42])=[O:17])=[O:13])=[CH:5][CH:9]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared analogously to Example 1a from tert.-butyl 5-chloro-thiophene-2-carboxylic acid and (R)-2-amino-propionate with TBTU and NMM in THF.
Sources & evidence
- ORD record
- ord-8f4b3566191e416c96e521dd4b17495a
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07732466B2
Reaction notes
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