Isatin → HCID 178517103, compound
Reaction equation
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=O)[C:2]1=[O:3].Cl.[NH2:13][OH:14].C([O-])(=O)C.[Na+]>C(O)C.O>[OH:14][N:13]=[C:4]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[NH:1][C:2]1=[O:3]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
To a suspension of 73.6 g of isatin in 1.2 l of ethanol was added a solution of 64.1 g of hydroxylamine hydrochloride and 64.1 g of sodium acetate in 500 ml of water. The mixture was stirred at room temperature for 30 minutes and concentrated. The residue was washed with water and recrystallized from ethanol to give 51.8 g (64%) of 3-(hydroxyimino)indolin-2-one as yellow crystals.
Workup
- concentrationconcentrated
- washThe residue was washed with water
- customrecrystallized from ethanol
Sources & evidence
- ORD record
- ord-abd1439ced1d4ae5952032b23374c2f9
- Source dataset
- uspto-grants-2001_03
- Patent number
- US06207836B1
Reaction notes
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