Tetrahydrofuran → 5-Bromo-1-{(3SR,4RS)-3-(3,4-dichloro-phenyl)-4-[(3-fluoro-4-trifluoromethyl-benzyl)-methyl-amino]-pyrrolidin-1-yl}-pentan-1-one
Reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=[O:7])[Cl:8].[CH2:36]([N:37]([CH2:38][CH3:39])[CH2:40][CH3:41])[CH3:42].[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[Cl:9][c:10]1[cH:11][c:12]([CH:17]2[CH:18]([N:22]([CH3:23])[CH2:24][c:25]3[cH:26][c:27]([F:35])[c:28]([C:31]([F:32])([F:33])[F:34])[cH:29][cH:30]3)[CH2:19][NH:20][CH2:21]2)[cH:13][cH:14][c:15]1[Cl:16]>>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=[O:7])[N:20]1[CH2:19][CH:18]([N:22]([CH3:23])[CH2:24][c:25]2[cH:26][c:27]([F:35])[c:28]([C:31]([F:32])([F:33])[F:34])[cH:29][cH:30]2)[CH:17]([c:12]2[cH:11][c:10]([Cl:9])[c:15]([Cl:16])[cH:14][cH:13]2)[CH2:21]1Participants
5
