Dimethylformamide → N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide

HRID 1538536

Reaction equation

HRID 1538536 reaction equation
[CH2:25]([CH3:26])[c:27]1[n:28][n:29]([CH3:35])[c:30]([C:32](=[O:33])[OH:34])[cH:31]1.[CH3:36][N:37]([CH3:38])[CH:39]=[O:40].[CH3:45][N:46]([CH3:47])[C:48](=[O:49])[CH3:50].[NH2:1][c:2]1[cH:3][c:4]([O:5][c:6]2[cH:7][cH:8][c:9]3[n:10]([n:11]2)[cH:12][c:13]([NH:15][C:16](=[O:17])[CH:18]2[CH2:19][CH2:20]2)[n:14]3)[cH:21][cH:22][c:23]1[F:24].[S:41]([Cl:42])([Cl:43])=[O:44]>>[NH:1]([c:2]1[cH:3][c:4]([O:5][c:6]2[cH:7][cH:8][c:9]3[n:10]([n:11]2)[cH:12][c:13]([NH:15][C:16](=[O:17])[CH:18]2[CH2:19][CH2:20]2)[n:14]3)[cH:21][cH:22][c:23]1[F:24])[C:32]([c:30]1[n:29]([CH3:35])[n:28][c:27]([CH2:25][CH3:26])[cH:31]1)=[O:33]

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 31374DimethylacetamideHCID 8205653-ethyl-1-methyl-1H-pyrazole-5-carboxylic acidHCID 57505446N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Product 1

HCID 24767988N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide

Sources & evidence

ORD record
ord-339124a1108a43fd82b49cae9c660517
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Linked notes

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