Potassium Cation → 5-Chloro-2-(trifluoromethyl)pyridine

Reaction equation

[CH3:19][N:20]1[CH2:21][CH2:22][CH2:23][C:24]1=[O:25].[CH3:3][Si:4]([C:5]([F:6])([F:7])[F:8])([CH3:9])[CH3:10].[Cl:11][c:12]1[cH:13][cH:14][c:15]([I:18])[n:16][cH:17]1.[Cu:26][I:27].[F-:1].[K+:2]>>[C:5]([F:6])([F:7])([F:8])[c:15]1[cH:14][cH:13][c:12]([Cl:11])[cH:17][n:16]1

Participants

Reactant 6

HCID 813Potassium Cation

HCID 13387N-methyl-2-pyrrolidone

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 28179Fluoride Ion

HCID 552549(Trifluoromethyl)trimethylsilane

HCID 111181485-Chloro-2-iodopyridine

Product 1

HCID 135326585-Chloro-2-(trifluoromethyl)pyridine

Sources & evidence

ORD record: ord-a38c0dcc9c924aa292de2c21e904a6a7
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…