Potassium Cation → 1-[3-Fluoro-4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

HRID 154608

Reaction equation

HRID 154608 reaction equation
[CH2:9]1[O:10][CH2:11][CH2:12][CH2:13]1.[CH3:1][Si:2]([C:3]([F:4])([F:5])[F:6])([CH3:7])[CH3:8].[CH3:51][OH:52].[Cl:47][CH:48]([Cl:49])[Cl:50].[F:20][c:21]1[c:22]([CH:23]=[O:24])[cH:25][cH:26][c:27]([N:29]2[C:30](=[O:41])[N:31]([c:34]3[cH:35][n:36][cH:37][cH:38][c:39]3[CH3:40])[CH2:32][CH2:33]2)[cH:28]1.[K+:14].[K+:15].[O-:16][C:17]([O-:18])=[O:19].[O:42]=[CH:43][N:44]([CH3:45])[CH3:46]>>[C:3]([F:4])([F:5])([F:6])[CH:23]([c:22]1[c:21]([F:20])[cH:28][c:27]([N:29]2[C:30](=[O:41])[N:31]([c:34]3[cH:35][n:36][cH:37][cH:38][c:39]3[CH3:40])[CH2:32][CH2:33]2)[cH:26][cH:25]1)[OH:24]

Participants

9

Reactant 8

HCID 813Potassium Cation2×HCID 887MethanolHCID 6212ChloroformHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 552549(Trifluoromethyl)trimethylsilaneHCID 596361642-Fluoro-4-[3-(4-methyl-pyridin-3-yl)-2-oxo-imidazolidin-1-yl]-benzaldehyde

Product 1

HCID 596362271-[3-Fluoro-4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

Sources & evidence

ORD record
ord-c4479f807cef49cf85612bd9fb99c537
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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