1,2-Dichloroethane → 2-fluoro-6-methoxy-N-[1-(4-methoxy-benzyl)-3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-benzamide

HRID 1556790

Reaction equation

HRID 1556790 reaction equation
[CH2:44]([Cl:45])[CH2:46][Cl:47].[CH3:13][O:14][c:15]1[cH:16][cH:17][c:18]([CH2:19][n:20]2[n:21][c:22](-[c:26]3[n:27][c:28]4[c:29]([nH:30]3)[cH:31][cH:32][c:33]([CH2:35][N:36]3[CH2:37][CH2:38][O:39][CH2:40][CH2:41]3)[cH:34]4)[c:23]([NH2:25])[cH:24]2)[cH:42][cH:43]1.[F:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[c:7]([O:11][CH3:12])[cH:8][cH:9][cH:10]1.[O:58]=[CH:59][N:60]([CH3:61])[CH3:62].[OH:48][n:49]1[c:50]2[c:51]([cH:52][cH:53][cH:54][cH:55]2)[n:56][n:57]1>>[F:1][c:2]1[c:3]([C:4](=[O:6])[NH:25][c:23]2[c:22](-[c:26]3[n:27][c:28]4[c:29]([nH:30]3)[cH:31][cH:32][c:33]([CH2:35][N:36]3[CH2:37][CH2:38][O:39][CH2:40][CH2:41]3)[cH:34]4)[n:21][n:20]([CH2:19][c:18]3[cH:17][cH:16][c:15]([O:14][CH3:13])[cH:43][cH:42]3)[cH:24]2)[c:7]([O:11][CH3:12])[cH:8][cH:9][cH:10]1

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 27373602-Fluoro-6-methoxybenzoic acidHCID 1784908051-(4-methoxy-benzyl)-3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-ylamine

Product 1

HCID 1784908092-fluoro-6-methoxy-N-[1-(4-methoxy-benzyl)-3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-benzamide

Sources & evidence

ORD record
ord-8aedcaad14894b5aa9f65a08fefb841c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Linked notes

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