Chloride → Thiophene-2-carboxylic acid [4-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

Reaction equation

[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[Cl-:28].[NH2:9][c:10]1[cH:11][cH:12][c:13]([C:14](=[O:15])[c:16]2[cH:17][cH:18][c:19]3[c:23]([cH:24]2)[NH:22][C:21](=[O:25])[CH2:20]3)[cH:26][cH:27]1.[s:1]1[c:2]([C:6](=[O:7])[Cl:8])[cH:3][cH:4][cH:5]1>>[s:1]1[c:2]([C:6](=[O:7])[NH:9][c:10]2[cH:11][cH:12][c:13]([C:14](=[O:15])[c:16]3[cH:17][cH:18][c:19]4[c:23]([cH:24]3)[NH:22][C:21](=[O:25])[CH2:20]4)[cH:26][cH:27]2)[cH:3][cH:4][cH:5]1

Participants

Reactant 4

HCID 312Chloride

HCID 8028Tetrahydrofuran

HCID 789282-Thiophenecarbonyl chloride

HCID 592564856-(4-Amino-benzoyl)-1,3-dihydro-indol-2-one

Product 1

HCID 86610381Thiophene-2-carboxylic acid [4-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

Sources & evidence

ORD record: ord-f0c600e61ee34810bebea571c3143348
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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