Tetrahydrofuran → Tert-butyl 4-(1-hydroxy-2-methylpropan-2-yl)piperazine-1-carboxylate

Reaction equation

[Al+3:23].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([C:14]([CH3:15])([CH3:16])[C:17](=[O:18])[O:19][CH2:20][CH3:21])[CH2:12][CH2:13]1.[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[H-:22].[H-:25].[H-:26].[H-:27].[Li+:24]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([C:14]([CH3:15])([CH3:16])[CH2:17][OH:18])[CH2:12][CH2:13]1

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 28486Lithium ion

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 57420344HCID 57420344, compound

Product 1

HCID 57420345Tert-butyl 4-(1-hydroxy-2-methylpropan-2-yl)piperazine-1-carboxylate

Sources & evidence

ORD record: ord-9e6578f3d0584ff9bbb5fa2c619535b7
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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