Dimethyl Sulfoxide → 7H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile

Reaction equation

[C-:22]#[N:23].[CH3:25][S:26]([CH3:27])=[O:28].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[nH:8][cH:9][cH:10]2.[K+:24].[Na:21].[OH2:29].[c:11]1([CH3:12])[cH:13][cH:14][c:15]([S:16]([OH:17])=[O:18])[cH:19][cH:20]1>>[c:2]1([C:22]#[N:23])[c:3]2[c:4]([n:5][cH:6][n:7]1)[nH:8][cH:9][cH:10]2

Participants

Reactant 7

HCID 679Dimethyl Sulfoxide

HCID 813Potassium Cation

HCID 962Water

HCID 5975Cyanide

HCID 10818p-Toluenesulfinic acid

HCID 53566827H-Pyrrolo(2,3-d)pyrimidine, 4-chloro-

HCID 5360545Sodium

Product 1

HCID 552884807H-Pyrrolo[2,3-d]pyrimidine-4-carbonitrile

Sources & evidence

ORD record: ord-3f669c83835a41b2b640d3c5aeb69cbe
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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