Dimethylformamide → (Dimethylaminomethylene)diphosphonic acid
Reaction equation
[CH3:1][N:2]([CH3:5])[CH:3]=O.[P:6]([OH:9])([OH:8])[OH:7].P(Cl)(Cl)Cl>O>[CH3:1][N:2]([CH3:5])[CH:3]([P:6]([OH:9])(=[O:7])[OH:8])[P:6]([OH:9])(=[O:8])[OH:7]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
73.1 parts of dimethyl formamide were mixed with 41 parts by phosphorous acid and this mixture was reacted with 137.3 parts of phosphorus trichloride at about 70°C. A viscous mass was formed, which after about an hour was treated with 180 parts of water. The solution so obtained was filtered and treated with acetone. A precipitate was formed which was further treated as described in Example 1. N,N-dimethyl-1-aminomethane-1,1-diphosphonic acid was obtained in a yield of 76%, based on PCl3.
Workup
- customA viscous mass was formed
- customThe solution so obtained
- filtrationwas filtered
- additiontreated with acetone
- customA precipitate was formed which
- additionwas further treated
Sources & evidence
- ORD record
- ord-aabf04f12de0420fbebc4dab97d29ef4
- Source dataset
- uspto-grants-1976_09
- Patent number
- US03979385
Reaction notes
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