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Potassium Carbonate → HCID 21699153, compound

HRID 1597175
Notes
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Reaction equation

HRID 1597175 reaction equation
[C:1]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:6]=1[OH:13])([OH:3])=[O:2].[N+:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1F)([O-:16])=[O:15].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[C:1]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:6]=1[O:13][C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([N+:14]([O-:16])=[O:15])[CH:18]=1)([OH:3])=[O:2]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 738951-Fluoro-2-nitrobenzeneHCID 12287720Benzeneacetic acid, 2-hydroxy-4-methoxy-

Product 1

HCID 21699153HCID 21699153, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228
Dimethylformamide
Solvent

Procedure

A solution of 2-carboxymethyl-5-methoxyphenol (34.1 g, 0.187 mol), 2-nitrofluorobenzene (19.7 mL, 0.187 mol), and K2CO3 (65 g, 0.467 mol) in DMF (200 mL) was heated to 110° C. for 18 h. The solution was diluted with water (200 mL) and extracted with ethyl acetate. The ethyl acetate layer was concentrated to give the crude title compound which was used as is for the next step (57 g).

Workup

  1. extractionextracted with ethyl acetate
  2. concentrationThe ethyl acetate layer was concentrated

Sources & evidence

ORD record
ord-0f08e5cb7eeb47358a6196c8b55e7c4f
Source dataset
uspto-grants-2001_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06294531B1

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes