Hydrochloric Acid → 4-(2-Chlorophenyl)-4-cyanopiperidine hydrochloride
Reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1([C:22]#[N:23])[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1>CCOC(C)=O>[ClH:2].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1([C:22]#[N:23])[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of EtOAc saturated with HCl (200 ml) was added to 4-(2-chlorophenyl)-4-cyano-N-(1,1-dimethylethoxycarbonyl)piperidine, (880 mg, 2.74 mmol). The resulting mixture was allowed to react for 1 hour at room temperature. The EtOAc was removed in vacuo affording 4-(2-Chlorophenyl)-4-cyanopiperidine hydrochloride as a white solid.
Workup
- customto react for 1 hour at room temperature
- customThe EtOAc was removed in vacuo
Sources & evidence
- ORD record
- ord-ddfc09c87fc4446b92d6a7c31ebb57a7
- Source dataset
- uspto-grants-1999_11
- Patent number
- US05977115
Reaction notes
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