Potassium Iodide → Batoprazine
Reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[O:10][C:9](=[O:12])[CH:8]=[CH:7]2.Cl.Cl[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]Cl.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>ClC1C=CC=CC=1>[O:10]1[C:11]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[N:1]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH:7]=[CH:8][C:9]1=[O:12]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
N-(coumarin-8-yl)-piperazine was prepared by reacting 8-aminocoumarin with an excess of bis(2-chloroethyl)amine hydrochloride in the presence of potassium carbonate and then of potassium iodide, the reaction being carried out under reflux in chlorobenzene.
Sources & evidence
- ORD record
- ord-f8533c2bb7764576924fa62b38338bd6
- Source dataset
- uspto-grants-1993_03
- Patent number
- US05194437
Reaction notes
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