Tetrahydrofuran → 3-(5-Methyl-3-phenyl-isoxazol-4-yl)-3-oxo-propionitrile

HRID 163957

Reaction equation

HRID 163957 reaction equation
[C:1](#[N:2])[CH2:3][C:4](=[O:5])[OH:6].[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH2:7]([Li:8])[CH2:9][CH2:10][CH3:11].[CH3:12][c:13]1[c:14]([C:24]([Cl:25])=[O:26])[c:15](-[c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[n:16][o:17]1>>[C:1](#[N:2])[CH2:3][C:4](=[O:6])[c:14]1[c:13]([CH3:12])[o:17][n:16][c:15]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 9740Cyanoacetic acidHCID 856245-Methyl-3-phenylisoxazole-4-carbonyl chlorideHCID 178418339Butyllithium

Product 1

HCID 234356403-(5-Methyl-3-phenyl-isoxazol-4-yl)-3-oxo-propionitrile

Sources & evidence

ORD record
ord-99104f7c9f594d14b2c750445c940fcc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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