Potassium Carbonate → N-[6-(3-amino-4-methylphenoxy)imidazo[1,2-b]pyridazin-2-yl]-2-cyclopropylacetamide

HRID 1663824

Reaction equation

HRID 1663824 reaction equation
[CH:1]1([CH2:4][C:5]([NH:7][C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][C:13](I)=[N:12][N:11]3[CH:17]=2)=[O:6])[CH2:3][CH2:2]1.[NH2:18][C:19]1[CH:20]=[C:21]([OH:26])[CH:22]=[CH:23][C:24]=1[CH3:25].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[NH2:18][C:19]1[CH:20]=[C:21]([CH:22]=[CH:23][C:24]=1[CH3:25])[O:26][C:13]1[CH:14]=[CH:15][C:10]2[N:11]([CH:17]=[C:8]([NH:7][C:5](=[O:6])[CH2:4][CH:1]3[CH2:3][CH2:2]3)[N:9]=2)[N:12]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 178203-Amino-p-cresolHCID 574410302-cyclopropyl-N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)acetamide

Product 1

HCID 57505559N-[6-(3-amino-4-methylphenoxy)imidazo[1,2-b]pyridazin-2-yl]-2-cyclopropylacetamideYield 47%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using 2-cyclopropyl-N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)acetamide (300 mg, 0.877 mmol), 3-amino-4-methylphenol (216 mg, 1.754 mmol), potassium carbonate (182 mg, 1.316 mmol) and N,N-dimethylformamide (3 mL), and by a reaction in the same manner as in Example 191, the title compound (138 mg, 47%) was obtained as a orange powder.

Workup

  1. customby a reaction in the same manner as in Example 191

Sources & evidence

ORD record
ord-4a0ed433e77145d68dbeb5674c9a79ec
Source dataset
uspto-grants-2011_10
Patent number
US08034812B2

Linked notes

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