Hydrochloric Acid → N4-(3,4-Dimethoxy-phenyl)-N2,N4-dimethyl-quinazoline-2,4-diamine

Reaction equation

[CH3:26][NH2:27].[Cl:2][c:3]1[n:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[c:11]([N:13]([CH3:14])[c:15]2[cH:16][c:17]([O:23][CH3:24])[c:18]([O:21][CH3:22])[cH:19][cH:20]2)[n:12]1.[ClH:1].[ClH:25].[Na+:28].[Na+:29].[O-:30][C:31](=[O:32])[O-:33]>>[c:3]1([NH:27][CH3:26])[n:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[c:11]([N:13]([CH3:14])[c:15]2[cH:16][c:17]([O:23][CH3:24])[c:18]([O:21][CH3:22])[cH:19][cH:20]2)[n:12]1

Participants

Reactant 5

HCID 313Hydrochloric Acid2×

HCID 923Sodium Ion2×

HCID 6329Methylamine

HCID 19660Carbonate Ion

HCID 11771849(2-Chloro-quinazolin-4-yl)-(3,4-dimethoxy-phenyl)-methyl-amine

Product 1

HCID 59242114N4-(3,4-Dimethoxy-phenyl)-N2,N4-dimethyl-quinazoline-2,4-diamine

Sources & evidence

ORD record: ord-36a3b8bd01744e92b8516994c6af28e9
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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