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Lithium Hydroxide → (7E)-8-{2-[(4-tert-Butylbenzyl)oxy]phenyl}-6-[2-(4-cyanophenyl)ethyl]oct-7-enoic acid

HRID 1672704
Notes
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Reaction equation

HRID 1672704 reaction equation
[C:1]([C:5]1[CH:40]=[CH:39][C:8]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2/[CH:17]=[CH:18]/[CH:19]([CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][C:34]([C:37]#[N:38])=[CH:33][CH:32]=2)[CH2:20][CH2:21][CH2:22][CH2:23][C:24]([O:26]CC)=[O:25])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Li+]>C1COCC1.O>[C:1]([C:5]1[CH:40]=[CH:39][C:8]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2/[CH:17]=[CH:18]/[CH:19]([CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][C:34]([C:37]#[N:38])=[CH:33][CH:32]=2)[CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 57831336HCID 57831336, compound

Product 1

HCID 57864418(7E)-8-{2-[(4-tert-Butylbenzyl)oxy]phenyl}-6-[2-(4-cyanophenyl)ethyl]oct-7-enoic acid

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

A solution of 798 mg (1.48 mmol) of ethyl 7E-8-[2-(4-tert-butylbenzyloxy)phenyl]-6-[2-(4-cyanophenyl)ethyl]oct-7-enoate in 20 ml of THF and 20 ml of water is mixed with 71 mg (2.97 mmol) of lithium hydroxide and stirred at 50° C. for 12 hours. Cooling is followed by dilution with water and diethyl ether and separation of the phases. The aqueous phase is acidified with 1 M hydrochloric acid and extracted with diethyl ether. The organic phase is washed with saturated sodium chloride solution, dried over sodium sulfate and concentrated. 700 mg (1.4 mmol, 93% of theory) of the title compound are obtained.

Workup

  1. temperatureCooling
  2. customis followed by dilution with water and diethyl ether and separation of the phases
  3. extractionextracted with diethyl ether
  4. washThe organic phase is washed with saturated sodium chloride solution
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-4552b927af7848fdbf0513a2172c4c50
Source dataset
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07998988B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes