Tetrahydrofuran → (4,4-Difluorocyclohexyl)methanol

Reaction equation

[Al+3:15].[CH2:20]1[O:21][CH2:22][CH2:23][CH2:24]1.[F:1][C:2]1([F:13])[CH2:3][CH2:4][CH:5]([C:8](=[O:9])[O:10][CH2:11][CH3:12])[CH2:6][CH2:7]1.[H-:14].[H-:17].[H-:18].[H-:19].[Li+:16]>>[F:1][C:2]1([F:13])[CH2:3][CH2:4][CH:5]([CH2:8][OH:9])[CH2:6][CH2:7]1

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 28486Lithium Cation

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 2779138Ethyl-4,4-difluorocyclohexane carboxylate

Product 1

HCID 21184133(4,4-Difluorocyclohexyl)methanol

Sources & evidence

ORD record: ord-039acf77858743eeba437e2205ef4b87
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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