1,4-Dioxane → 1-Cyclopropylpiperazine

A solution of tert-butyl 4-cyclopropylpiperazine-1-carboxylate (0.792 g, 3.50 mmol) in 4M HCl in 1,4-dioxane (4.37 mL, 17.50 mmol) was stirred at room temperature for 3 h under nitrogen. The reaction mixture was filtered and washed with ether to afford crude 1-cyclopropylpiperazine (0.659 g) as a white solid. The crude product was purified by ion exchange chromatography, using a SCX column. The desired product was eluted from the column using 3.5M NH3/MeOH and pure fractions were evaporated to dryness to afford 1-cyclopropylpiperazine (0.264 g, 59.7%) as a yellow oil.

1. filtrationThe reaction mixture was filtered
2. washwashed with ether
3. customto afford crude 1-cyclopropylpiperazine (0.659 g) as a white solid
4. customThe crude product was purified by ion exchange chromatography
5. washThe desired product was eluted from the column
6. customwere evaporated to dryness

ORD record

ord-7cd9b3c6ffb040d58b94fc1a4073fa4f

Source dataset

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07737149B2