Dimethylformamide → 2-[4-(4-{7-[2-(Methanesulfonyl-methyl-amino)-phenyl]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)-piperidin-1-yl]-acetamide

HRID 168488

Reaction equation

HRID 168488 reaction equation
[CH3:52][N:53]([CH3:54])[CH:55]=[O:56].[CH:24]([N:25]([CH2:26][CH3:27])[CH:28]([CH3:29])[CH3:30])([CH3:31])[CH3:32].[NH2:33][c:34]1[c:35]([O:50][CH3:51])[cH:36][c:37]([CH:40]2[CH2:41][CH2:42][N:43]([CH2:46][C:47](=[O:48])[NH2:49])[CH2:44][CH2:45]2)[cH:38][cH:39]1.[OH:1][c:2]1[n:3][n:4]2[c:5]([cH:6][n:7]1)[c:8]([CH3:23])[cH:9][c:10]2-[c:11]1[c:12]([N:17]([S:18](=[O:19])(=[O:20])[CH3:21])[CH3:22])[cH:13][cH:14][cH:15][cH:16]1>>[c:2]1([NH:33][c:34]2[c:35]([O:50][CH3:51])[cH:36][c:37]([CH:40]3[CH2:41][CH2:42][N:43]([CH2:46][C:47](=[O:48])[NH2:49])[CH2:44][CH2:45]3)[cH:38][cH:39]2)[n:3][n:4]2[c:5]([cH:6][n:7]1)[c:8]([CH3:23])[cH:9][c:10]2-[c:11]1[c:12]([N:17]([S:18](=[O:19])(=[O:20])[CH3:21])[CH3:22])[cH:13][cH:14][cH:15][cH:16]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 569459622-[4-(4-Amino-3-methoxy-phenyl)-piperidin-1-yl]-acetamideHCID 178422626HCID 178422626, compound

Product 1

HCID 569458462-[4-(4-{7-[2-(Methanesulfonyl-methyl-amino)-phenyl]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino}-3-methoxy-phenyl)-piperidin-1-yl]-acetamide

Sources & evidence

ORD record
ord-5bfdf1a37400405a92336d896b023f20
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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