4-Aminotetrahydropyran → [2-(4-Chloro-phenyl)-2H-indazol-3-yl]-(tetrahydro-pyran-4-yl)-amine
Reaction equation
[CH2:1]([N:5]([C:15]1[N:16]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[N:17]=[C:18]2[C:23]=1[CH:22]=[CH:21][CH:20]=[CH:19]2)C(NC1CCCCC1)=O)[CH2:2][CH2:3]C.[O:31]1CCC(N)[CH2:33][CH2:32]1>CN1CCCC1=O>[Cl:30][C:27]1[CH:28]=[CH:29][C:24]([N:16]2[C:15]([NH:5][CH:1]3[CH2:33][CH2:32][O:31][CH2:3][CH2:2]3)=[C:23]3[C:18]([CH:19]=[CH:20][CH:21]=[CH:22]3)=[N:17]2)=[CH:25][CH:26]=1Participants
4
Procedure
In analogy to the procedure described in example 4.1, 3-chloro-2-(4-chloro-phenyl)-2H-indazole (Ardakani, Manouchehr; Smalley, Robert K.; Smith, Richard H., Synthesis (1979), (4), 308-9) was reacted with tetrahydro-pyran-4-ylamine ([38041-19-9]) in N-methyl 2-pyrrolidone for 48 h at 175° C. in a sealed tube to give the title compound as yellow solid. MS: m/e=328.4 [M+H+].