N,N'-Diethylthiourea → 3-Ethyl-2-ethylimino-4-(4-methyl-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrochloride

HRID 1703886

Reaction equation

HRID 1703886 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH2:16]([NH:18][C:19]([NH:21][CH2:22][CH3:23])=[S:20])[CH3:17]>C(OC(C)C)(C)C>[ClH:1].[CH2:22]([N:21]1[C:3]([C:5]2[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=2)([OH:4])[CH2:2][S:20][C:19]1=[N:18][CH2:16][CH3:17])[CH3:23]

Participants

4

Reactant 2

HCID 2735009N,N'-DiethylthioureaHCID 136287832-Chloro-4'-methyl-3'-sulfamoylacetophenone

Product 1

HCID 227604333-Ethyl-2-ethylimino-4-(4-methyl-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrochloride

Reagents, catalysts & solvents 1

HCID 7914Diisopropyl EtherSolvent

Procedure

5 g of 2-chloro-4'-methyl-3'-sulfamoylacetophenone and 2.7 g of 1,3-diethylthiourea were reacted as prescribed in Example 12. After addition of 200 ml of diisopropyl ether the solvent was decanted and the oily end product was crystallized under ethyl acetate heated to 40° to 50° C. Colorless solid body, melting point: 160° C. (decomposition).

Workup

  1. customwas decanted
  2. customthe oily end product was crystallized under ethyl acetate
  3. temperatureheated to 40° to 50° C

Sources & evidence

ORD record
ord-c4108d65d4e24c309ab0e54c0c8529d7
Source dataset
uspto-grants-1978_11
Patent number
US04125614

Linked notes

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