Hydrochloric Acid → 1-Boc-4-(4-Ethoxycarbonyl-4,5-dihydrothiazol-2-yl)piperidine

HRID 174117

Reaction equation

HRID 174117 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH:14]=[O:15])[CH2:12][CH2:13]1.[CH2:17]([CH3:18])[O:19][C:20]([CH:21]([NH2:22])[CH2:23][SH:24])=[O:25].[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[CH3:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1.[ClH:16]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([C:14]2=[N:22][CH:21]([C:20]([O:19][CH2:17][CH3:18])=[O:25])[CH2:23][S:24]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 3297Ethyl 2-amino-3-sulfanylpropanoateHCID 8471TriethylamineHCID 1514430tert-Butyl 4-formylpiperidine-1-carboxylate

Product 1

HCID 666795511-Boc-4-(4-Ethoxycarbonyl-4,5-dihydrothiazol-2-yl)piperidine

Sources & evidence

ORD record
ord-4b98e0d02595455f9bbf0c8939e20c5f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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