Water → 7-iodo-6-methoxybenzofuran-3(2H)-one
Reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[CH2:7][O:8][C:4]=2[C:3]=1[I:12].[C:13](=O)([O-])[O-].[K+].[K+].CI.O>CN(C=O)C>[I:12][C:3]1[C:4]2[O:8][CH2:7][C:6](=[O:9])[C:5]=2[CH:10]=[CH:11][C:2]=1[O:1][CH3:13]Participants
6
Procedure
A solution of 6-hydroxy-7-iodobenzofuran-3(2H)-one (2.58 g, 9.35 mmol) in DMF (37 mL) was added with potassium carbonate (1.55 g, 11.2 mmol) and methyl iodide (0.697 mL, 11.2 mmol), and the mixture was stirred at room temperature for 13 hours. The reaction mixture was added with water (400 mL), and the precipitated solid was collected by filtration to obtain 7-iodo-6-methoxybenzofuran-3(2H)-one (1.35 g, 49%).
Workup
- filtrationthe precipitated solid was collected by filtration
Sources & evidence
- ORD record
- ord-f4b3193167cb4c51a7e1184338971551
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09156827B2
Reaction notes
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