HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Trifluoroacetic acid → HCID 17862562, compound

HRID 1766936
Notes
Print preview

Reaction equation

HRID 1766936 reaction equation
[CH2:1]([O:4][C:5]([O:7][CH2:8][C:9]1[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][C:10]=1[C:11]([O:13]CC1C=CC(OC)=CC=1)=[O:12])=[O:6])[CH:2]=[CH2:3].C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>C1(C)C=CC=CC=1>[CH2:1]([O:4][C:5]([O:7][CH2:8][C:9]1[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][C:10]=1[C:11]([OH:13])=[O:12])=[O:6])[CH:2]=[CH2:3]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 21110471HCID 21110471, compound

Product 1

HCID 17862562HCID 17862562, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of 4-methoxybenzyl 2-[(allyloxycarbonyl)oxymethyl]-5-cyanobenzoate (3 g, 7.9 mmol) and anisole (3.5 g) was cooled to 0° C., and trifluoroacetic acid (10 ml) was added thereto. The mixture was stirred at room temperature for 15 minutes, diluted with toluene, and the solvent was distilled off under reduced pressure. The residue was subjected to chromatography on a silica gel (35 g) column (eluent; dichloromethane:ethyl acetate=1:1) to afford the title compound (1.95 g, 95% yield) as a colorless solid (mp. 81-83° C.)

Workup

  1. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-cfd4a0f16e9a4b948a3a5d451a6b57cb
Source dataset
uspto-grants-2007_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07230023B2

Reaction notes

Loading…

On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes