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Toluene → HCID 21110467, compound

HRID 1766943
Notes
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Reaction equation

HRID 1766943 reaction equation
[CH2:1]([O:4][P:5]([O:11][CH2:12][C:13]1[C:14]([C:18]([OH:20])=O)=[CH:15][O:16][CH:17]=1)([O:7][CH2:8][CH:9]=[CH2:10])=[O:6])[CH:2]=[CH2:3].CN(C)C=O.C(Cl)(=O)C([Cl:29])=O.C1(C)C=CC=CC=1>ClCCl>[CH2:1]([O:4][P:5]([O:11][CH2:12][C:13]1[C:14]([C:18]([Cl:29])=[O:20])=[CH:15][O:16][CH:17]=1)([O:7][CH2:8][CH:9]=[CH2:10])=[O:6])[CH:2]=[CH2:3]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 1140TolueneHCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 21110466HCID 21110466, compound

Product 1

HCID 21110467HCID 21110467, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-[[Bis(allyloxy)phosphoryl]oxymethyl]-3-furoic acid (500 mg, 1.65 mmol) obtained from Example 35-(5) was dissolved in dichloromethane (10 ml), and N,N-dimethylformamide (0.03 ml) and oxalyl chloride (0.7 g, 5.5 mmol) were added thereto. The mixture was stirred at room temperature for 1 hour, and toluene was added thereto, then the solvent was distilled off under reduced pressure to give crude 4-[[bis(allyloxy)phosphoryl]oxymethyl]-3-furoyl chloride.

Workup

  1. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-273c1c2740634604a0a6ac7d5177b2ad
Source dataset
uspto-grants-2007_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07230023B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes