Methanesulfonic Acid → 2-Hydroxy-4-methoxy-3'-methoxy-benzophenone

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15](O)=[O:16].CS(O)(=O)=O>>[OH:9][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[C:15]([C:14]1[CH:18]=[CH:19][CH:20]=[C:12]([O:11][CH3:10])[CH:13]=1)=[O:16]

Participants

Reactant 3

HCID 6395Methanesulfonic Acid

HCID 90073-Methoxyphenol

HCID 114613-Methoxybenzoic Acid

Product 1

HCID 113228592-Hydroxy-4-methoxy-3'-methoxy-benzophenone

Procedure

Substituted 2-hydroxybenzophenones may be prepared as illustrated by exemplary reaction in Scheme 8. Reaction of 3-methoxyphenol with 3-methoxybenzoic acid in the presence of Al2O3 and CH3SO3H produces 2-hydroxy-4-methoxy-3′-methoxy-benzophenone.

Workup

customas illustrated by exemplary reaction in Scheme 8

Sources & evidence

ORD record: ord-3c32ec942a1c49508778682f3b33b671
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07235674B2

Reaction notes

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