4-Chloropyridine → [2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine

HRID 17742

Reaction equation

[Cl:1][C:2]1[CH:33]=[CH:32][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH:17]=[C:16]([C:18]4[CH:27]=[CH:26][C:21]([O:22][CH2:23][CH2:24][NH2:25])=[CH:20][CH:19]=4)[N:15]=[C:14]3[CH2:28][CH:29]([CH3:31])[CH3:30])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.Cl[C:35]1[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=1>CN(C=O)C>[Cl:1][C:2]1[CH:33]=[CH:32][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH:17]=[C:16]([C:18]4[CH:27]=[CH:26][C:21]([O:22][CH2:23][CH2:24][NH:25][C:35]5[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=5)=[CH:20][CH:19]=4)[N:15]=[C:14]3[CH2:28][CH:29]([CH3:30])[CH3:31])=[CH:11][CH:12]=2)=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 100 °C

Procedure

2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine, the product of Example 512, was treated with 4-chloropyridine in DMF and was heated at 100° C. Aqueous workup and chromatography on silica gel afforded Example 519. (Yield: 80 mg)

Workup

customAqueous workup and chromatography on silica gel afforded Example 519

Sources & evidence

ORD record: ord-f4c5cc306db44e75b408cc77c88ae295
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07737285B2

Linked notes

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