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Methylhydrazine → 3-{4H,5H,6H-cyclopenta[b]thiophen-2-yl}-5-(diethoxymethyl)-1-methyl-1H-pyrazole

HRID 1774601
Notes
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Reaction equation

HRID 1774601 reaction equation
[S:1]1[C:5]([C:6](Cl)=O)=[CH:4][C:3]2[CH2:9][CH2:10][CH2:11][C:2]1=2.C(N(CC)CC)C.[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[C:23]#[CH:24])[CH3:20].[CH3:28][NH:29][NH2:30]>O1CCOCC1.C(O)C.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cu](I)I>[S:1]1[C:5]([C:6]2[CH:24]=[C:23]([CH:22]([O:25][CH2:26][CH3:27])[O:21][CH2:19][CH3:20])[N:29]([CH3:28])[N:30]=2)=[CH:4][C:3]2[CH2:9][CH2:10][CH2:11][C:2]1=2
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

9

Reactant 4

HCID 6061MethylhydrazineHCID 8471TriethylamineHCID 662853,3-DiethoxypropyneHCID 190880195,6-Dihydro-4H-cyclopenta[b]thiophene-2-carbonyl chloride

Product 1

HCID 900924713-{4H,5H,6H-cyclopenta[b]thiophen-2-yl}-5-(diethoxymethyl)-1-methyl-1H-pyrazoleYield 75.3%

Reagents, catalysts & solvents 4

HCID 83717
Copper iodide
Catalyst
HCID 178418476HCID 178418476, compoundCatalyst
HCID 702EthanolSolvent
HCID 312751,4-DioxaneSolvent

Procedure

A solution of 5,6-dihydro-4H-cyclopenta[b]thiophene-2-carbonyl chloride (1.75 g, 9.36 mmol) in anhydrous dioxane (20 mL) was bubbled with argon for 10 minutes. Triethylamine (3.27 mL, 23.41 mmol) was added and the bubbling was maintained for 5 minutes. Bis(triphenylphosphine)palladium(II) dichloride (219 mg, 0.31 mmol), copper iodide (119 mg, 0.62 mmol) and propargylaldehyde diethyl acetal (1.12 mL, 7.80 mmol) were added, and the reaction mixture was stirred for 2 hours at room temperature, under argon atmosphere. The solution was filtered and water (20 mL) was added to the filtrate. Layers were separated, and the aqueous layer was extracted with dichloromethane (2×20 mL). The combined organic layers were washed with a saturated solution of sodium hydrogenocarbonate (20 mL), dried over sodium sulfate and concentrated in vacuo. The residue was added to a solution of methylhydrazine (0.82 mL, 15.6 mmol) in ethanol (80 mL). The reaction mixture was stirred overnight at room temperature, concentrated in vacuo and dissolved in ethyl acetate (20 mL). The organic layer was successively washed with water (20 mL) and brine (20 mL) before being dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (cyclohexane/ethyl acetate 100/0 to 90/10) to provide 3-{4H,5H,6H-cyclopenta[b]thiophen-2-yl}-5-(diethoxymethyl)-1-methyl-1H-pyrazole (37a) (1.80 g, 5.87 mmol, 75%).

Workup

  1. temperaturethe bubbling was maintained for 5 minutes
  2. filtrationThe solution was filtered
  3. additionwater (20 mL) was added to the filtrate
  4. customLayers were separated
  5. extractionthe aqueous layer was extracted with dichloromethane (2×20 mL)
  6. washThe combined organic layers were washed with a saturated solution of sodium hydrogenocarbonate (20 mL)
  7. dry with materialdried over sodium sulfate
  8. concentrationconcentrated in vacuo
  9. stirringThe reaction mixture was stirred overnight at room temperature
  10. concentrationconcentrated in vacuo
  11. dissolutiondissolved in ethyl acetate (20 mL)
  12. washThe organic layer was successively washed with water (20 mL) and brine (20 mL)
  13. dry with materialbefore being dried over sodium sulfate
  14. concentrationconcentrated in vacuo
  15. customThe residue was purified by flash chromatography on silica gel (cyclohexane/ethyl acetate 100/0 to 90/10)

Sources & evidence

ORD record
ord-8c3b765f3da441e9a5cd4d7effbadc51
Source dataset
uspto-grants-2016_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09260395B2

Reaction notes

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