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Water → (E)-(2S,3S)-3-[(S)-2-(4-butoxy-phenyl)-1-carboxy-ethylcarbamoyl]-12,12-difluoro-2-hydroxy-2-(2-methoxy-ethyl)-nonadec-4-enoic acid

HRID 1779150
Notes
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Reaction equation

HRID 1779150 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C@H:13]([NH:18][C:19]([C@@H:21](/[CH:31]=[CH:32]/[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][C:39]([F:48])([F:47])[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])[C@@:22]([OH:30])([CH2:26][CH2:27][O:28][CH3:29])[C:23]([OH:25])=[O:24])=[O:20])[C:14]([O:16]C)=[O:15])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].O.C(N(CC)CC)C.[Br-].[Li+]>C(#N)C>[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C@H:13]([NH:18][C:19]([C@@H:21](/[CH:31]=[CH:32]/[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][C:39]([F:47])([F:48])[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])[C@@:22]([OH:30])([CH2:26][CH2:27][O:28][CH3:29])[C:23]([OH:25])=[O:24])=[O:20])[C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 82050Lithium BromideHCID 60150052(E)-(2S,3S)-3-[(S)-2-(4-butoxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-12,12-difluoro-2-hydroxy-2-(2-methoxy-ethyl)-nonadec-4-enoic acid

Product 1

HCID 73291867(E)-(2S,3S)-3-[(S)-2-(4-butoxy-phenyl)-1-carboxy-ethylcarbamoyl]-12,12-difluoro-2-hydroxy-2-(2-methoxy-ethyl)-nonadec-4-enoic acid
Yield 54%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
50 °C

Procedure

(E)-(2S,3S)-3-[(S)-2-(4-butoxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-12,12-difluoro-2-hydroxy-2-(2-methoxy-ethyl)-nonadec-4-enoic acid (No. 5514403, 100 mg, 0.142 mmol) was dissolved in acetonitrile (1.0 mL), and subsequently water (0.005 mL, 0.278 mmol), triethylamine (0.118 mL, 0.847 mmol) and anhydrous lithium bromide (244 mg, 2.81 mmol) were sequentially added at room temperature. The mixture was stirred at 50° C. for 11.5 hours. After cooling the reaction solution to room temperature, a preparative HPLC was performed to obtain 51.1 mg of the title compound (0.07629 mmol, 54% yield).

Workup

  1. temperatureAfter cooling the reaction solution to room temperature

Sources & evidence

ORD record
ord-fc5fd11b03e9439b8f34bce2023be719
Source dataset
uspto-grants-2016_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09266853B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes