Aminoacetaldehyde dimethyl acetal → HCID 178495964, compound
Reaction equation
[ClH:1].[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][C:8](=[NH:12])OCC.[CH3:13][O:14][CH:15]([O:18][CH3:19])[CH2:16][NH2:17]>O1CCCC1>[ClH:1].[CH3:13][O:14][CH:15]([O:18][CH3:19])[CH2:16][NH:17][C:8](=[NH:12])[CH2:7][C:3]1[S:2][CH:6]=[CH:5][CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of ethyl 2-thiopheneethanimidate monohydrochloride (ester) (0.05 mol) in tetrahydrofuran (100 ml) was stirred under nitrogen. 2,2-dimethoxyethanamine (0.05 mol) was added portionwise upon cooling and the mixture was stirred overnight. The mixture was evaporated, yielding 15.6 g (100%) of N-(2,2-dimethoxyethyl)-2-thiopheneethanimidamide monohydrochloride (interm. 1).
Workup
- temperatureupon cooling
- stirringthe mixture was stirred overnight
- customThe mixture was evaporated
Sources & evidence
- ORD record
- ord-c50596464eb645bfb2eb263e8d736dbc
- Source dataset
- uspto-grants-1997_05
- Patent number
- US05629308
Reaction notes
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