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Hydrochloric Acid → HCID 67117384, compound

HRID 1784709
Notes
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Reaction equation

HRID 1784709 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]3)=[CH:16][CH:15]=2)[CH2:9]1)=O)(C)(C)C.[ClH:27]>CO.C(OCC)(=O)C>[ClH:27].[ClH:27].[ClH:27].[CH3:26][N:23]1[CH2:24][CH2:25][N:20]([C:17]2[CH:16]=[CH:15][C:14]([CH:10]3[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]3)=[CH:19][CH:18]=2)[CH2:21][CH2:22]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 536289531,1-Dimethylethyl 3-[4-(4-methyl-1-piperazinyl)phenyl]-1-piperidinecarboxylate

Product 1

HCID 67117384HCID 67117384, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 3-(4-(4-methylpiperazin-1-yl)-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (2.0 g, 5.56 mmol) in methanol (20 mL) was added 4N hydrochloric acid in ethyl acetate (20 mL) at room temperature. After stirring for 1 h, the resulting suspension was concentrated in vacuo. The residue was washed with ethyl acetate to furnish 3-(4-(4-methylpiperazin-1-yl)-phenyl)-piperidine trihydrochloride (1.84 g, 4.99 mmol, 90%) as white crystals.

Workup

  1. concentrationthe resulting suspension was concentrated in vacuo
  2. washThe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-8d8506b1c879405883e373c628aeb02c
Source dataset
uspto-grants-2009_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07504411B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes