Pyridine → HCID 178433931, compound

HRID 1786703

Reaction equation

HRID 1786703 reaction equation
[O:1]=[C:2]1[C:7]([C:8]([NH:10][NH2:11])=O)=[CH:6][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:4][NH:3]1.[C:18]([NH2:21])(=S)[CH3:19].C(N(CC)CC)C.N1C=CC=CC=1>C(O)CCC>[CH3:19][C:18]1[NH:21][C:8]([C:7]2[C:2](=[O:1])[NH:3][N:4]=[C:5]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)[CH:6]=2)=[N:10][N:11]=1

Participants

6

Reactant 4

HCID 1049PyridineHCID 8471TriethylamineHCID 2723949ThioacetamideHCID 127902392,3-Dihydro-3-oxo-6-(4-pyridinyl)-4-pyridazinecarboxylic acid hydrazide

Product 1

HCID 178433931HCID 178433931, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 100 mg of 3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazine-4-carboxylic acid hydrazide, 130 mg thioacetamide, 87 mg triethylamine, 1 ml of pyridine and 5 ml of butanol is refluxed for 15 hours. After cooling and stirring at room temperature, a solid precipitated is collected by filtration, washed with cold isopropanol and dried in vacuo.

Workup

  1. temperatureis refluxed for 15 hours
  2. temperatureAfter cooling
  3. customa solid precipitated
  4. filtrationis collected by filtration
  5. washwashed with cold isopropanol
  6. customdried in vacuo

Sources & evidence

ORD record
ord-9975cf0fb56142daa5f77fd28abbd97c
Source dataset
uspto-grants-2009_03
Patent number
US07507734B2

Linked notes

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