Tetrahydrofuran → N-(5-bromo-1,3-thiazol-2-yl)-N-[2-(1,3-dioxoisoindol-2-yl)-3-phenylpropyl]acetamide

HRID 178837

Reaction equation

HRID 178837 reaction equation
[Br:1][c:2]1[cH:3][n:4][c:5]([NH:7][C:8]([CH3:9])=[O:10])[s:6]1.[CH2:65]1[O:66][CH2:67][CH2:68][CH2:69]1.[O:51]=[C:52]([O:53][CH:54]([CH3:55])[CH3:56])[N:57]=[N:58][C:59]([O:60][CH:61]([CH3:62])[CH3:63])=[O:64].[OH:11][CH2:12][CH:13]([CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[N:21]1[C:22](=[O:31])[c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2[C:29]1=[O:30].[c:32]1([P:33]([c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[cH:46][cH:47][cH:48][cH:49][cH:50]1>>[Br:1][c:2]1[cH:3][n:4][c:5]([N:7]([C:8]([CH3:9])=[O:10])[CH2:12][CH:13]([CH2:14][c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)[N:21]2[C:22](=[O:31])[c:23]3[cH:24][cH:25][cH:26][cH:27][c:28]3[C:29]2=[O:30])[s:6]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 331870N-(2-Hydroxy-1-benzylethyl)phthalimideHCID 3502602-Acetamido-5-bromo-1,3-thiazole

Product 1

HCID 68993603N-(5-bromo-1,3-thiazol-2-yl)-N-[2-(1,3-dioxoisoindol-2-yl)-3-phenylpropyl]acetamide

Sources & evidence

ORD record
ord-56bb4d2f67934043a9f75b203f9ff079
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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