Ethanol → Bis(diisopropylamino)chlorophosphine

HRID 1791093Notes

Reaction equation

HRID 1791093 reaction equation
P(Cl)(Cl)[Cl:2].C(NC(C)C)(C)C.[CH:12]([N:15]([PH:19][N:20]([CH:24]([CH3:26])[CH3:25])[CH:21]([CH3:23])[CH3:22])[CH:16]([CH3:18])[CH3:17])([CH3:14])[CH3:13].C(O)C>C1(C)C=CC=CC=1>[CH:24]([N:20]([P:19]([N:15]([CH:12]([CH3:14])[CH3:13])[CH:16]([CH3:17])[CH3:18])[Cl:2])[CH:21]([CH3:23])[CH3:22])([CH3:26])[CH3:25]

Participants

6

Reactant 4

HCID 702EthanolHCID 7912DiisopropylamineHCID 24387Phosphorus trichlorideHCID 498731Bis(diisopropylamino)-phosphine

Product 1

HCID 2733425Bis(diisopropylamino)chlorophosphine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Bis(diisopropylamino)chlorophosphine was synthesized by reacting phosphorous trichloride and diisopropylamine in toluene. Fifty ml of the resulting bis(diisopropylamino)phosphine was placed in a 250 ml flask and 3.01 ml of ethanol added slowly over a two minute period and the reaction allowed to proceed for several days. After filtering the mixture and removing the solvent, the structure of the bis(diisopropylamino)ethylphosphite ester reagent was analyzed by 31P and 1H NMR (31P NMR in CD3CN 125.9 ppm).

Workup

  1. waitto proceed for several days
  2. filtrationAfter filtering the mixture
  3. customremoving the solvent

Sources & evidence

ORD record
ord-3c0d343101884f729a2fce032cbee5eb
Source dataset
uspto-grants-2006_07
Patent number
US07074569B2

Reaction notes

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