Hydrochloric Acid → 4-Methyloxan-4-amine hydrochloride
Reaction equation
[N:1]([C:4]1([CH3:10])[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1)=C=O.[ClH:11]>C1COCC1>[ClH:11].[CH3:10][C:4]1([NH2:1])[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 4-isocyanato-4-methyltetrahydro-2H-pyran (D10) (520 mg, 3.68 mmol) in THF (30 mL) was treated with 5 M hydrochloric acid (4.05 mL, 20.3 mmol) and stirred at room temperature overnight. The mixture was then concentrated under vacuum to yield the title compound (D11) (820 mg, 3.52 mmol, 95% yield) as a pale green solid.
Workup
- concentrationThe mixture was then concentrated under vacuum
Sources & evidence
- ORD record
- ord-08f5c8cf2c31484495c0f5992e00a869
- Source dataset
- uspto-grants-2013_01
- Patent number
- US08344000B2
Reaction notes
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