Piperidine → 4-Piperidinylbut-1-ene

HRID 1824513

Reaction equation

HRID 1824513 reaction equation
Br[CH2:2][CH2:3][CH:4]=[CH2:5].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[N:6]1([CH2:7][CH2:8][CH:9]=[CH2:10])[CH2:11][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 21241Homoallyl bromide

Product 1

HCID 45622824-Piperidinylbut-1-eneYield 93.4%

Procedure

4-Bromobut-1-ene (1.35 g) was treated with piperidine (1.7 g) and heated at reflux for 3 hours. The mixture was cooled to ambient temperature, filtered and the residue washed with ether (50 mL). The combined filtrate and washings were evaporated to give the title compound (1.3 g).

Workup

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. filtrationfiltered
  4. washthe residue washed with ether (50 mL)
  5. customThe combined filtrate and washings were evaporated

Sources & evidence

ORD record
ord-adb29397f4884d54a3b13354f001a0f2
Source dataset
uspto-grants-2006_05
Patent number
US07041827B2

Linked notes

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