Piperidine → 4-Piperidinylbut-1-ene

HRID 1824547

Reaction equation

HRID 1824547 reaction equation
Br[CH2:2][CH2:3][CH:4]=[CH2:5].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[N:6]1([CH2:7][CH2:8][CH:9]=[CH2:10])[CH2:11][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 21241Homoallyl bromide

Product 1

HCID 45622824-Piperidinylbut-1-eneYield 93.4%

Procedure

4-Bromobut-1-ene (1.35 g) was treated with piperidine (1.7 g) and heated at reflux for 3 hours. The mixture was cooled to ambient temperature, filtered and the residue washed with ether (50 mL). The combined filtrate and washings were evaporated to give the title compound (1.3 g).

Workup

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. filtrationfiltered
  4. washthe residue washed with ether (50 mL)
  5. customThe combined filtrate and washings were evaporated

Sources & evidence

ORD record
ord-5c51527d0b6f4cf0b91aba41d78fbf5c
Source dataset
uspto-grants-2006_05
Patent number
US07041828B2

Linked notes

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