Hydrochloric Acid → 1-(1-benzofuran-5-yl)propan-2-one
Reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH:11](N)[CH3:12])=[CH:9][C:4]=2[CH:3]=[CH:2]1.Cl.C(OCC)(=[O:17])C>C(OCC)C>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11](=[O:17])[CH3:12])=[CH:9][C:4]=2[CH:3]=[CH:2]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
This amine was dissolved in 20 mL ethyl acetate and then a 1 N solution of hydrogen chloride in diethyl ether was added dropwise. The resulting slurry was filtered, the solid washed with 3 mL ethyl acetate, and the solid dried under vacuum to provide 0.548 gm (91%) of the title compound.
Workup
- filtrationThe resulting slurry was filtered
- washthe solid washed with 3 mL ethyl acetate
- customthe solid dried under vacuum
Sources & evidence
- ORD record
- ord-33537da81d28443381d818022afc5fe4
- Source dataset
- uspto-grants-2006_05
- Patent number
- US07045545B1
Reaction notes
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