Methyl iodide → 3-Methoxy-4-methyl-2-nitropyridine
Reaction equation
[OH:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8].[C:12](=O)([O-])[O-].[Cs+].[Cs+].CI.C(OCC)(=O)C>CN(C)C=O.CCCCCC>[CH3:12][O:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8]Participants
7
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Procedure
3-Hydroxy-4-methyl-2-nitropyridine (5 g) was dissolved in dimethylformamide (50 ml), added with cesium carbonate (11.6 g) and methyl iodide (13.7 g), and then the mixture was stirred overnight at room temperature. The reaction mixture was added with ethyl acetate and hexane, washed with water and dried over magnesium sulfate, and then the solvent was evaporated under reduced pressure to obtain the title compound (quantitative).
Workup
- washwashed with water
- dry with materialdried over magnesium sulfate
- customthe solvent was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-d8b863c73e0e4ca18bc54436aa86d8dd
- Source dataset
- uspto-grants-2006_06
- Patent number
- US07056917B2
Reaction notes
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