[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[CH2:5][NH:6][C:7]1[C:8]2[N:21]([CH3:22])[N:20]=[C:19]([CH2:23][CH2:24][CH3:25])[C:9]=2[N:10]=[C:11]([CH2:13][CH2:14][C:15]([O:17]C)=[O:16])[N:12]=1.[OH-].[Na+].Cl>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[CH2:5][NH:6][C:7]1[C:8]2[N:21]([CH3:22])[N:20]=[C:19]([CH2:23][CH2:24][CH3:25])[C:9]=2[N:10]=[C:11]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])[N:12]=14.3 g of methyl 3-[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-propionate are dissolved in 30 ml of tetrahydrofuran (THF) and, after addition of 10 ml of 10% NaOH, stirred at 60° for 8 hours. After addition of 10% HCl, the deposited crystals are separated off and recrystallized from methanol. 3.7 g of 3-[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionic acid, m.p. 178°, are obtained.
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