Methyl 3-(2-(tert-butoxy)-2-oxoethoxy)benzoate → [3-(Methoxycarbonyl)phenoxy]acetic acid
Reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][CH:19]=1)[O:8][CH2:9][C:10]([O:12]C(C)(C)C)=[O:11])=[O:4]>FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1.ClCCl>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][CH:19]=1)[O:8][CH2:9][C:10]([OH:12])=[O:11])=[O:4]Participants
5
Procedure
A solution of t-butyl [3-(methoxycarbonyl)phenoxy]acetate in trifluoroacetic acid (1 kg), anisole (100 mL) and dichloromethane (1 L) was stirred at room temperature for 48 hours. The reaction mixture was concentrated and then the residue was crystallized from diisopropyl ether to obtain the title compound (467 g, 86%) as a white solid.
Workup
- concentrationThe reaction mixture was concentrated
- customthe residue was crystallized from diisopropyl ether
Sources & evidence
- ORD record
- ord-b38f9c98b5864a879d1efd653c9006d9
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08946264B2
Reaction notes
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