4-Chlorophenol → 3-(4-Chlorophenoxy)propan-1-amine

HRID 1844405Notes

Reaction equation

HRID 1844405 reaction equation
Cl[C:2]1[CH:12]=[CH:11][CH:10]=[C:9](Cl)[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][NH2:8].[Cl:14]C1C=CC=C(Cl)C=1O.ClC1C=CC(O)=CC=1>>[Cl:14][C:11]1[CH:10]=[CH:9][C:3]([O:4][CH2:5][CH2:6][CH2:7][NH2:8])=[CH:2][CH:12]=1

Participants

4

Reactant 3

HCID 46844-ChlorophenolHCID 68992,6-DichlorophenolHCID 33042863-(2,6-Dichlorophenoxy)propan-1-amine

Product 1

HCID 64846543-(4-Chlorophenoxy)propan-1-amineYield 85%

Procedure

Intermediate 11 (150 mg, 0.808 mmol, 85% yield) was prepared as a white powder following the procedure described for Intermediate 9 replacing 2,6-dichlorophenol with 4-chlorophenol as starting material. LC-MS (ESI) 186 (M+H), RT=1.41 min (Method B).

Sources & evidence

ORD record
ord-b8e99765dcef43beb74ddbd54c20503d
Source dataset
uspto-grants-2015_02
Patent number
US08946430B2

Reaction notes

Loading…