Hydrochloric Acid → 1-(2-Aminopyrimidin-4-yl)ethan-1-one
Reaction equation
C[O:2][C:3]([C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH2:13])[N:8]=1)(OC)[CH3:4].Cl>O1CCCC1>[NH2:13][C:9]1[N:8]=[C:7]([C:3](=[O:2])[CH3:4])[CH:12]=[CH:11][N:10]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of 4-(1,1-dimethoxyethyl)pyrimidin-2-amine (2a) (180 g) in tetrahydrofuran (2 L) was added 2M hydrochloric acid solution (980 mL) and stirring continued at room temperature overnight. Most of the solvent was removed in vacuo and remaining aqueous solution was poured into an aqueous saturated sodium hydrogen carbonate solution. The sandy coloured precipitate was filtered off and dried in vacuo at 40° C. to give the title compound (112 g).
Workup
- customMost of the solvent was removed in vacuo
- additionwas poured into an aqueous saturated sodium hydrogen carbonate solution
- filtrationThe sandy coloured precipitate was filtered off
- customdried in vacuo at 40° C.
Sources & evidence
- ORD record
- ord-7be1c8cddcd04102a2e8421fe63470c4
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08952001B2
Reaction notes
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