Dichloromethane → HCID 68613712, compound
Reaction equation
Cl[CH2:2][Cl:3].C(Cl)(=O)C(Cl)=O.[C:10]([C:13]1[CH:21]=[CH:20][C:16](C(O)=O)=[C:15]([CH3:22])[CH:14]=1)(=[O:12])[CH3:11]>CN(C)C=O>[C:10]([C:13]1[CH:21]=[CH:20][C:16]([CH2:2][Cl:3])=[C:15]([CH3:22])[CH:14]=1)(=[O:12])[CH3:11]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
28 ml of dichloromethane, 4 ml of oxalyl chloride, and a drop of N,N-dimethylformamide were added to 5.0 g of 4-acetyl-2-methylbenzoic acid, and the mixture was stirred for 3 hours at room temperature. After removing the solvent by distilling under reduced pressure, 5.6 g of crude 4-acetyl-2-methylbenzyl chloride was obtained.
Workup
- customAfter removing the solvent
- distillationby distilling under reduced pressure
Sources & evidence
- ORD record
- ord-7cc8f63a881b46209ee2126ddfb3cc6d
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08952175B2
Reaction notes
Loading…