3,5-Diamino-1,2,4-triazole → HCID 178508251, compound

HRID 1851217

Reaction equation

HRID 1851217 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([NH2:7])[NH:4][N:3]=1.[C:8]1([CH:14]([C:20](OCC)=[O:21])[C:15](OCC)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(N(CCCC)CCCC)CCC>[NH2:1][C:2]1[N:6]=[C:5]2[N:7]=[C:15]([OH:16])[C:14]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[C:20]([OH:21])[N:4]2[N:3]=1

Participants

4

Reactant 2

HCID 150783,5-Diamino-1,2,4-triazoleHCID 66514Diethyl phenylmalonate

Product 1

HCID 178508251HCID 178508251, compound

Reagents, catalysts & solvents 1

HCID 7622TributylamineSolvent

Procedure

A solution of 9.0 g 3,5-diamino-1,2,4-triazole and 22.4 mL diethyl phenylmalonate in N,N-dibutylbutan-1-amine was heated under microwave irradiation to 180° C. for 8 h. The reaction mixture formed two layers after cooling to room temperature. The top layer was removed and the solvent of the lower layer was evaporated. The residue was treated with water and acidified with 5N HCl. The precipitated product was collected by filtration and dried. The crude product was used without further purification.

Workup

  1. customThe reaction mixture formed two layers
  2. customThe top layer was removed
  3. customthe solvent of the lower layer was evaporated
  4. additionThe residue was treated with water
  5. filtrationThe precipitated product was collected by filtration
  6. customdried
  7. customThe crude product was used without further purification

Sources & evidence

ORD record
ord-66d812d7ed2d46ae9b8c90c93a1783d1
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Linked notes

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